BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery

Andressa F. Bonjorno, Renata Pavan, Guilherme F. S. Fernandes, Cauê B. Scarim, Daniele Castagnolo, Jean Leandro Dos Santos

Frontiers in Chemistry, vol. 12, 2024, p. 1358539

Liposome-siderophore conjugates loaded with moxifloxacin serve as a model for drug delivery against Mycobacterium tuberculosis

Camila M. Ribeiro, Cesar A. Roque-Borda, Maria C. Franzini, Karyn F. Manieri, Fernanda M. Demarqui, Débora L. Campos, Rachel T. Machado, Isabel C. Silva, Marcela T. Luiz, Leonardo D. Di Filippo, Patrícia B. Silva, Márcia C. Rocha, Sônia N. Báo, Domiziana Masci, Guilherme F. S. Fernandes, Daniele Castagnolo, Marlus Chorilli, Fernando R. Pavan

International Journal of Pharmaceutics, vol. 655, 2024, p. 124050

Rapamycin-loaded nanostructured lipid carrier modified with folic acid intended for breast cancer therapy

Camila Rodero, Marcela Luiz, Mariana Sato, Fernanda Boni, Guilherme F. S. Fernandes, Jean Santos, Ana Lopez, Juan Irache, Marlus Chorilli

International Journal of Pharmaceutics, 2024, p. 124954

Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches

Débora Campos, Christian Canales, Fernanda Demarqui, Guilherme F. S. Fernandes, Camila Santos, João Prates, Ingrid Silva, Karine Barros-Cordeiro, Sônia Báo, Leonardo Andrade, Nathália Abichabki, Luísa Zacharias, Marli Campos, Jean Santos, Fernando Pavan

Frontiers in Microbiology, vol. 15, 2024, p. 2024

Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis

Diego E. Chiba, Guilherme F. S. Fernandes, Jean L. Santos, Cauê B. Scarim

Medicinal Chemistry Research, 2024

Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery

Guilherme F. S. Fernandes, Seong-Heun Kim, Daniele Castagnolo

RSC Advances, vol. 14, 2024, p. 30396

Development of Novel Membrane Disrupting Lipoguanidine Compounds Sensitizing Gram-Negative Bacteria to Antibiotics

Seong-Heun Kim, Charlotte K. Hind, Guilherme F. S. Fernandes, Jingyue Wu, Dorothy Semenya, Melanie Clifford, Caleb Marsh, Silvia Anselmi, A. James Mason, Kenneth D. Bruce, J. Mark Sutton, Daniele Castagnolo

ACS Medicinal Chemistry Letters, 2024

Synthesis and Anti-Mycobacterium tuberculosis Activity of Imidazo[2,1-b][1,3]oxazine Derivatives Against Multidrug-Resistant Strains

G.F.S. Fernandes, K.F. Manieri, A.F. Bonjorno, D.L. Campos, C.M. Ribeiro, F.M. Demarqui, D.A.G. Ruiz, N.M. Nascimento-Junior, W.A. Denny, A.M. Thompson, F.R. Pavan, J.L. Dos Santos

ChemMedChem, vol. 18(12), 2023, pp. e202300015

Oxazolidinones as Versatile Scaffolds in Medicinal Chemistry

G.F.S. Fernandes, C.B. Scarim, S.H. Kim, W. Jingyue, D. Castagnolo

RSC Medicinal Chemistry, vol. 14, 2023, pp. 823-847

Phthalimide as a versatile pharmacophore scaffold: Unlocking its diverse biological activities

G.F.S. Fernandes, J.R. Lopes, J.L. Dos Santos, C.B. Scarim

Drug Development Research, vol. 84(7), 2023, pp. 1346-1375

Tuberculosis - Integrated Studies for a Complex Disease

J.L.B. Prates, G.F.S. Fernandes, C.N. Rodriguez-Silva, J.L. Santos

The Challenges of Antitubercular Drug Discovery, 2023, pp. 483-498

Tuberculosis Drug Discovery: Challenges and New Horizons

G.F.S. Fernandes, A.M. Thompson, D. Castagnolo, W.A. Denny, J.L. Dos Santos

Journal of Medicinal Chemistry, vol. 65, 2022, pp. 7489–7531

Tapping into the antitubercular potential of 2,5-dimethylpyrroles: a structure-activity relationship interrogation

D. Semenya, M. Touitou, D. Masci, C.M. Ribeiro, F.R. Pavan, G.F.S. Fernandes, B. Gianibbi, F. Manetti, D. Castagnolo

European Journal of Medicinal Chemistry, vol. 237, 2022, p. 114404

Design, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activity

L.C. Clementino, G.F.S. Fernandes, I.M. Prokopczyk, W.C. Laurindo, D. Toyama, B.P. Motta, A.M. Baviera, F. Henrique-Silva, J.L. Santos, M.A.S. Graminha

PLoS ONE, vol. 16, 2021, pp. e0259008

Benzofuroxan Derivatives as Potent Agents Against Multidrug-Resistant Mycobacterium tuberculosis

G.F.S. Fernandes, D.L. Campos, I.C. Da Silva, J.L.B. Prates, A.R. Pavan, F.R. Pavan, J.L. Dos Santos

ChemMedChem, vol. 16, 2021, pp. 1268-1282

Synthesis and pharmacological evaluation of pomalidomide derivatives useful for sickle cell disease treatment

T.R.F. Melo, B.M. Dulmovits, G.F.S. Fernandes, C.M. De Souza, C. Lanaro, M. He, Y. Al Abed, M.C. Chung, L. Blanc, F.F. Costa, J.L. Dos Santos

Bioorganic Chemistry, vol. 114, 2021, p. 105077

Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers

P.L. Bosquesi, A.C.B. Melchio, A.R. Pavan, C. Lanaro, M.C. De Souza, R. Rusinova, R.C. Chelucci, K.P. Barbieri, G.F.S. Fernandes, I.Z. Carlos, O.S. Andersen, F.F. Costa, J.L. Santos

Bioorganic Chemistry, vol. 100, 2020, p. 103948

Furoxan derivatives demonstrated in vivo efficacy by reducing Mycobacterium tuberculosis to undetectable levels in a mouse model of infection

P.C. De Souza, G.F.S. Fernandes, L.B. Marino, C.M. Ribeiro, P.B. Da Silva, M. Chorilli, C.S.P. Silva, F.A. Resende, M.C. Solcia, R.A. De Grandis, C.A.S. Costa, S.H. Cho, Y. Wang, S.G. Franzblau, J.L. Dos Santos, F.R. Pavan

Biomedicine & Pharmacotherapy, vol. 130, 2020, p. 110592

A Critical Review of HPLC-based Analytical Methods for Quantification of Linezolid

G.F.S. Fernandes, H.R.N. Salgado, J.L. Santos

Critical Reviews in Analytical Chemistry, vol. 50, 2020, pp. 196-211

Boron in drug design: Recent advances in the development of new therapeutic agents

G.F.S. Fernandes, W.A. Denny, J.L. Santos

European Journal of Medicinal Chemistry, vol. 179, 2019, pp. 791-804

Recent advances in the discovery of small molecules targeting glioblastoma

G.F.S. Fernandes, B.C. Fernandes, V. Valente, J.L. Santos

European Journal of Medicinal Chemistry, vol. 164, 2019, pp. 8-26

Recent Advancement in Prodrugs

G.F.S. Fernandes, I.M. Prokopczyk, C. Man Chin, J.L. Santos

The progress of prodrugs in drug solubility, 2019, pp. 133-164

Heterocyclic N-oxides - A Promising Class of Agents Against Tuberculosis, Malaria and Neglected Tropical Diseases

G.F.S. Fernandes, A.R. Pavan, J.L. Santos

Current Pharmaceutical Design, vol. 24, 2018, pp. 1325-1340

Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation

T.R.F. Melo, C. Kumkhaek, G.F.S. Fernandes, M.E.L. Pires, R.C. Chelucci, K.P. Barbieri, F. Coelho, T.S.O. Capote, C. Lanaro, I.Z. Carlos, S. Marcondes, K. Chegaev, S. Guglielmo, R. Fruttero, C. Man Chin, F.F. Costa, G.P. Rodgers, J.L. Santos

European Journal of Medicinal Chemistry, vol. 154, 2018, pp. 341-353

Potential Molecular Targets for Antituberculosis Drug Discovery

G.F.S. Fernandes, C. Man Chin, J.L. Santos

Quimica Nova, vol. 40, 2017, pp. 572-585

Advances in Drug Discovery of New Antitubercular Multidrug-Resistant Compounds

G.F.S. Fernandes, C. Man Chin, J.L. Santos

Pharmaceuticals, vol. 10, 2017, p. 51

A Comparative Study of Conventional and Microwave-Assisted Synthesis of Quinoxaline 1,4-di-N-oxide N-acylhydrazones Derivatives Designed as Antitubercular Drug Candidates

G.F.S. Fernandes, E. Moreno-Viguri, M. Santivañez-Veliz, R. Paucar, C. Man Chin, S. Pérez-Silanes, J.L. Santos

Journal of Heterocyclic Chemistry, vol. 54, 2017, pp. 2380-2388

Isoniazid: A Review of Characteristics, Properties and Analytical Methods

G.F.S. Fernandes, H.R.N. Salgado, J.L. Santos

Critical Reviews in Analytical Chemistry, vol. 47, 2017, pp. 298-308

Epigenetic Regulatory Mechanisms Induced by Resveratrol

G.F.S. Fernandes, G. Silva, A.R. Pavan, D. Chiba, C. Man Chin, J.L. Santos

Nutrients, vol. 9, 2017, p. 1201

Design, Synthesis and Characterization of N-oxide-containing Heterocycles with In vivo Sterilizing Antitubercular Activity

G.F.S. Fernandes, P.C. Souza, E. Moreno-Viguri, M. Santivañez-Veliz, R. Paucar, S. Pérez-Silanes, K. Chegaev, S. Guglielmo, L. Lazzarato, R. Fruttero, C. Man Chin, P.B. Silva, M. Chorilli, M.C. Solcia, C.M. Ribeiro, C.S.P. Silva, L.B. Marino, P.L. Bosquesi, D.M. Hunt, L.P.S. Carvalho, C.A.S. Costa, S.H. Cho, Y. Wang, S.G. Franzblau, F.R. Pavan, J.L. Santos

Journal of Medicinal Chemistry, vol. 60, 2017, pp. 8647-8660

Synthesis and Biological Activity of Furoxan Derivatives Against Mycobacterium tuberculosis

G.F.S. Fernandes, P.C. Souza, L.B. Marino, K. Chegaev, S. Guglielmo, L. Lazzarato, R. Fruttero, C. Man Chin, F.R. Pavan, J.L Santos

European Journal of Medicinal Chemistry, vol. 123, 2016, pp. 523-531

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

D. Jornada, G.F.S. Fernandes, D. Chiba, T. Melo, J.L. Santos, C. Man Chin

Molecules, vol. 21, 2016, p. 42

Unraveling the Anticancer Effect of Curcumin and Resveratrol

A. Pavan, G. Silva, D. Jornada, D. Chiba, G.F.S. Fernandes, C. Man Chin, J.L. Santos

Nutrients, vol. 8, 2016, p. 628

Current Advances in Antitubercular Drug Discovery: Potent Prototypes and New Targets

G.F.S. Fernandes, D.H. Jornada, P.C. Souza, C. Man Ching, F.R. Pavan, J.L. Santos

Current Medicinal Chemistry, vol. 22, 2015, pp. 3133-3161

Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases

J.L. Santos, G.F.S. Fernandes, P.L. Bosquesi, L.B. Marino, C.Q.F. Leite, C. Man Chin, F.R Pavan

Tuberculosis Synthetic Organic Compounds as Potential Antitubercular Drugs: A Review of the Progress Made in the Last Five Years, 2014, pp. 231-266